Ethylamine → Acetamide, N-ethyl-2-phenyl- (7CI)

HRID 1957276Notes

Reaction equation

HRID 1957276 reaction equation
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11]([NH2:13])[CH3:12]>C1C=CC=CC=1>[CH2:11]([NH:13][C:8](=[O:9])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:12]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 7679Phenylacetyl chloride

Product 1

HCID 79591Acetamide, N-ethyl-2-phenyl- (7CI)

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

Dissolved 15 g (0.1 mol) of phenylacetyl chloride in 100 ml of benzene. While stirring on a magnetic stirrer, added 25 g of ethylamine (0.5 mol) into the benzene solution at 20°-30° C. After reaction, the solution was washed with water, dehydrated with anhydrous magnesium sulfate. The solvent was removed by rotary evaporator and the residue was purified by column chromatography as compound 3-1 to yield N-ethyl phenylacetamide as yellowish crystal. Yield, 14 g (85%).

Workup

  1. customAfter reaction
  2. washthe solution was washed with water
  3. customThe solvent was removed by rotary evaporator
  4. customthe residue was purified by column chromatography as compound 3-1

Sources & evidence

ORD record
ord-3acec732dbda4fbda8b89e0ed2a5ec01
Source dataset
uspto-grants-1998_07
Patent number
US05783605

Reaction notes

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