HCID 10505429, compound → HCID 10625577, compound

Participants

Reaction Steps

To a solution of 4,4'-di(2-quinolylmethoxy)benzophenone (992 mg, 2 mmol) in THF (20 mL) at -78° C. was added methylmagnesium bromide (3M solution in ethyl ether, 0.8 mL, 2.4 mmol) and the resulting mixture was stirred at room temperature for 12 hours. The mixture was then quenched with saturated aqueous NH4Cl and extracted with ethyl acetate. The extract was washed with water, brine, dried with anhydrous MgSO4 and concentrated in vacuo. The residue was chromatographed (silica gel, methylene chloride-ethyl acetate 4:1) to afford 920 mg of 1,1-bis(4-(2-quinolylmethoxy)phenyl)ethanol.

Provenance & Evidence