Triethylamine → 2-(2-Oxo-1,3,2-dioxaphospholan-2-yloxy)ethyl acrylate

Participants

Reaction Conditions

Reaction Steps

2-Hydroxyethyl acrylate (11.5 ml, 0.1 M) and triethylamine (14.6 ml) in dry diethyl ether (250 ml) were cooled to -25° C. under nitrogen as a solution of 2-chloro-2-oxo-1,3,2-dioxaphospholane (14.3 g) in dry diethyl ether was added over 20 minutes. The mixture was stirred for a further 1 hour at -20° C. and then allowed to warm to 10° C. over a further hour. The precipitate was filtered, washed with ethyl acetate (100 ml) and the combined filtrate and washings evaporated under reduced pressue to give a pale yellow oil (21 g).

Provenance & Evidence