HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-Methyl-1-(4-phenoxyphenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Phenoxybenzaldehyde | HCID 66139 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Methyl-1-(4-phenoxyphenyl)methanamine | HCID 10608640 | — |
Reaction Steps
4-Phenoxybenzaldehyde (10.0 g, 0.05 mol), excess methylamine and 1.5 g of 10% Pd/C in 200 mL of methanol were stirred under an atmosphere of hydrogen for 16 hours. After removal of the catalyst by filtration through a filter and (CELITE®), the filtrate was concentrated under reduced pressure to give the crude product as an oil. Chromatography on silica gel eluting with ethyl acetate gave the title compound in 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783593 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-30988cbc2d08475b8e3227298e8cc3bd |
| Source note | uspto-grants-1998_07 |