Potassium Carbonate → 3-(2-Cyclopropyl-2-oxo-ethyl)-5-methoxy-3H-[1,3,4]thiadiazol-2-one

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Reaction Steps

55 g of potassium carbonate are added to a solution of 26.4 g of 5-methoxy-3H-[1,3,4]-thiadiazol-2-one in 700 ml of dioxane and the reaction mixture is heated to 60°. Then 35 g of bromomethyl cyclopropyl ketone are added dropwise within a short period of time and the reaction mixture is stirred at 70° for 20 hours and then, at 20°, is filtered over Celite. The filtrate is concentrated by evaporation. The residue is stirred with diisopropyl ether and filtered with suction. 41 g of crystals of the title compound having a melting point of 98°-100° are thus obtained.

Provenance & Evidence