HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → Morpholine-4-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Morpholine-4-sulfonyl chloride | HCID 12798265 | — |
Reaction Steps
A solution of 4.6 g of sulfuryl chloride in acetonitrile was treated dropwise with 996 mg of morpholine at ambient temperature under an atmosphere of nitrogen. After complete addition, the mixture was refluxed for 16 h, cooled to room temperature, and concentrated in vacuo to yield the title product as a red oil. TLC: Rf=0.65 CH2Cl2. (1 H)-NMR (CDCl3) consistent with structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783701 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-df1adfb79c214d0089fd94edab297d1e |
| Source note | uspto-grants-1998_07 |