HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloromethyl phenyl sulphide → 2-Phenylthiomethyl-4-methylsaccharin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloromethyl phenyl sulphide | HCID 81623 | — |
| Reactant | 4-Methyl-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trione | HCID 15934075 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Phenylthiomethyl-4-methylsaccharin | HCID 70044768 | 46.3% |
Reaction Steps
A mixture of 1.0 g (0.005 mol) of 4-methylsaccharin, 0.33 g (0.001 mol) of TBAB and 1.2 g (0.0075 mol) of chloromethyl phenyl sulfide in 25 ml of toluene was heated under reflux for about sixteen hours and then cooled, diluted with ethyl acetate and the solution washed with aqueous bicarbonate and water. The organic layer was dried and taken to dryness to give 0.74 g of 2-phenylthiomethyl-4-methylsaccharin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783589 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-64e8433c9352484b910f4202543e4641 |
| Source note | uspto-grants-1998_07 |