HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 178455393, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (2S)-1-(2,3-Diaminophenoxy)-3-(dibenzylamino)propan-2-ol | HCID 54261304 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178455393 | HCID 178455393 | 96% |
Reaction Steps
(S)-[3-(N,N-Dibenzylamino)-2-hydroxypropoxy]-2,3-diaminobenzene (1g, 2.7mmol) was dissolved in N,N Dimethylformamide (10 mL) and imidazole (0.27g, 4.0 mmol) and tert-butyldimethylsilyl chloride (0.6g, 4.0 mmol) were added. The solution was stirred at ambient temperature for 18 hours and then was partitioned between chloroform and water. The combined organic extracts were dried over sodium sulfate and concentrated in vacuo to give the desired benzimidazole 1.3g (96%). NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05786356 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-7689a6e9e7f44f9b8cc50102f028cce5 |
| Source note | uspto-grants-1998_07 |