HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-hydroxyphenylacetate → HCID 14022788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-hydroxyphenylacetate | HCID 28310 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Sodium ethoxide | HCID 2723922 | — |
| Product | HCID 14022788 | HCID 14022788 | 64.3% |
Reaction Steps
115 g 4-hydroxy-phenylacetic acid ethyl ester is hydrogenated in a mixture of 10 ml one molar sodium ethylate solution and 350 ml ethanol for 72 hours at 160° C. and 200 bar using Raney-Nickel. The preparation is subsequently evaporated and the remaining oil is distilled in a high vacuum. 76.4 g 4-hydroxycyclohexane-acetic acid ethyl ester is obtained with a boiling point of 120°-121° C./2 mm Hg. TLC (mobile solvent: dichloromethane/methanol 9:1). Rf=0.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05786371 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-eb4b245169544e9b9052e35f43b260e4 |
| Source note | uspto-grants-1998_07 |