Ethanol → HCID 19068200, compound

HRID 1957527Notes

Reaction equation

HRID 1957527 reaction equation
C([O:4][CH:5]([C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][N:8]=1)[CH3:6])(=O)C.[OH-].[K+].C(O)C>O>[O:9]1[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:7]([CH:5]([OH:4])[CH3:6])=[N:8]1

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 19068203HCID 19068203, compound

Product 1

HCID 19068200HCID 19068200, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.6 g of 3-(1-acetoxyethyl)-1,2-benzisoxazole, 0.9 g of potassium hydroxide, 40 ml of ethanol and 3 ml of water is stirred for 1 h at room temperature. The reaction mixture is then concentrated under vacuum and diluted with water. This aqueous phase is extracted three times with diethyl ether, the combined ethereal extracts are then washed with a saturated solution of sodium chloride and dried over sodium sulfate, giving 1-(1,2-benzisoxazol-3-yl)ethanol as an oil having a refractive index nD20 of 1.5555.

Workup

  1. concentrationThe reaction mixture is then concentrated under vacuum
  2. additiondiluted with water
  3. extractionThis aqueous phase is extracted three times with diethyl ether
  4. washthe combined ethereal extracts are then washed with a saturated solution of sodium chloride
  5. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-e46a4847bc584047af11a68dbe52fe30
Source dataset
uspto-grants-1998_07
Patent number
US05786374

Reaction notes

Loading…