Potassium Carbonate → HCID 19068185, compound

Participants

Reaction Steps

2 g of 1-(6-hydroxy-1,2-benzisoxazol-3-yl)ethanone are dissolved in 20 ml of acetone, 2.1 g of potassium carbonate are added and then 3 g of 1-(bromomethyl)-3-(trifluoromethyl)benzene are added dropwise. The reaction mixture is then refluxed for 1 h. After cooling and filtration and concentrating the filtrate under vacuum, the crude product is taken up in ethyl acetate, the organic phase is washed once with water and once with a saturated solution of sodium chloride, dried over sodium sulfate and concentrated. Recrystallistion from ethyl acetate/hexane gives 1-(6-[3-(trifluoromethyl)benzyloxy]-1,2-benzisoxazol-3-yl)ethanone having a melting point of 130°-132° C.

Provenance & Evidence