Tetralin → HCID 19067930, compound

HRID 1957542Notes

Reaction equation

HRID 1957542 reaction equation
[CH2:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14]CC=C)[N:10]([CH2:18][CH:19]=[C:20]([CH3:22])[CH3:21])[C:9](=[O:23])[CH2:8][CH2:7]2)[CH:2]=[CH2:3].[CH2:24]1[C:33]2C(=CC=CC=2)CC[CH2:25]1>>[CH2:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([CH2:33][CH:24]=[CH2:25])[C:13]=1[OH:14])[N:10]([CH2:18][CH:19]=[C:20]([CH3:21])[CH3:22])[C:9](=[O:23])[CH2:8][CH2:7]2)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 8404TetralinHCID 19067990HCID 19067990, compound

Product 1

HCID 19067930HCID 19067930, compoundYield 78%

Procedure

10 Grams of 6-allyl-7-allyloxy-3,4-dihydro-1-prenyl-2(1H)-quinolinone obtained in Example 20 was dissolved in 50 ml of tetralin and stirred at 200° to 230° C. for 3 hours. After cooling, the reaction mixture was subjected to purification by passing through a silica gel column, there was obtained 7.8 g (78%) of 6,8-diallyl-3,4-dihydro-7-hydroxy-1-prenyl-2(1H)-quinolinone.

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture was subjected to purification

Sources & evidence

ORD record
ord-6c78aed923474e9bbd5c3b83010eeb53
Source dataset
uspto-grants-1998_07
Patent number
US05786367

Reaction notes

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