Butylamine → HCID 19067885, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-Bromobutyl)-5,7-diallyl-3,4-dihydro-6-hydroxy-2(1H)-quinolinone (1.9 g) prepared in Example 43 was dissolved in acetonitrile (50 ml), then n-butylamine (2 ml) was added and stirred at 80° C. for 4 hours. The reaction mixture was extracted with ethyl acetate, and the extract was washed with an aqueous solution saturated with sodium bicarbonate, next with water, then concentrated under reduced pressure. Thus obtained oily residual product was dissolved in ethanol, acidified by adding oxalic acid, then concentrated to dryness, and recrystallized from acetone, there was obtained of 1-(4-n-butylaminobutyl)-5,7-diallyl-3,4-dihydro-6-hydroxy-2(1H)-quinolinone.oxalate in 35% yield.

Provenance & Evidence