Hydrochloric Acid → HCID 19067980, compound

Participants

Reaction Conditions

Reaction Steps

1-(2-Cyanoethyl)-5,7-diallyl-3,4-dihydro-6-(2-tetrahydropyranyloxy)-2(1H)-quinolinone (1 g) obtained in Example 95 was dissolved in 50 ml of methanol, then 6N-hydrochloric acid was added thereto and stirred at 60° C. for 30 minutes so as to remove the tetrahydropyranyl group, and concentrated under reduced pressure to dryness. Thus obtained residual product was subjected to purification by means of a silica gel column chromatography, then recrystallized from ethyl acetate-n-hexane, there was obtained 1-(2-cyanoethyl)-5,7-diallyl-3,4-dihydro-6-hydroxy-2(1H)-quinolinone.

Provenance & Evidence