HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 19068171, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Tert-butyl 4-(3-iodopropyl)piperidine-1-carboxylate | HCID 9975355 | — |
| Reactant | HCID 178498603 | HCID 178498603 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 19068171 | HCID 19068171 | — |
Reaction Steps
A mixture of methyl 3-hydroxy-5-isoxazolecarboxylate (Aldrich) (3-5) (286 mg, 2.0 mmol), 3-4 (706 mg, 2.0 mmol), Cs2CO3 (650 mg, 2.0 mmol), and DMF (10 mL) was stirred at ambient temperature. After 72 hours the reaction mixture was diluted with ether and then washed with H2O and brine, dried (MgSO4), and concentrated. Flash chromatography (silica, 4% acetone/CH2Cl2) gave 3-6 as a colorless solid. Rf 0.54 (silica, 40 %EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05786373 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-18110f652a764c16bd5b52672752c62f |
| Source note | uspto-grants-1998_07 |