Sodium Hydroxide → 3-[4-(N-BOC-Piperidin-4-yl)butyloxy]isoxazole-5-carboxylic acid

Participants

Reaction Steps

A solution of 4-4 (2.7 g, 6.9 mmol), CH3OH (50 mL), and 1N NaOH (13.9 mL, 13.9 mmol) was stirred at ambient temperature for 1 h. The CH3OH was evaporated and the resulting aqueous portion acidified with 1M NaHSO4. The solution was extracted with EtOAc (3×) and then the extracts were combined, dried (MgSO4), and concentrated to give 4-5 (2.5 g) as a solid.

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