Sodium Hydroxide → HCID 178451887, compound

Participants

Reaction Steps

6-2 (162.5 mg, 0.42 mmol) was dissolved in 3 mL MeOH NaOH (1N, 0.5 mL, 0.5 mmol) was added; after 6 h additional NaOH (1N, 1 mL, 1 mmol) was added; after 1 day additional NaOH (1N, 1 mL, 1 mmol) was added. After three more days the mixture was heated at 50° for 6 h, then concentrated. The residue was taken up in water, pH adjusted to 5 with 5% KHSO4, extracted 3× with EtOAc, the combined organic extracts were washed with brine, dried (MgSO4), and concentrated providing acid 6-3. Rf 0.39 (9:1:1 CH2Cl2 /MeOH/HOAc);

Provenance & Evidence