反应详情

温度

-78 °C

In a Fischer-Porter tube, a mixture of 7-9 (10.2 g, 42 mmol) and DME (150 mL) was sequentially, treated with H2SO4 (6.4 mL, 0.12 mol), cooled to -78° C., and then condensed isobutylene (75 mL). The cooling both removed. After 2h, ice/water (250 mL) was added followed by washing with ether (2×). The aqueous phase was basified with aq 6N NaOH, then saturated with NaCl followed by extraction with EtOH (3×). The combined extracts were washed with brine, dried (MgSO4), and concentrated to give a white solid. This was dissolved in CHCl3 then treated with 1N HCl/ether (22 mL) then concentrated to give 7-4 as a glossy yellow solid.

1. washby washing with ether (2×)
2. extractionsaturated with NaCl followed by extraction with EtOH (3×)
3. washThe combined extracts were washed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customto give a white solid
7. concentrationthen concentrated