HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,11-Dihydro-5H-dibenz[b,e]azepine → HCID 54506243, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,11-Dihydro-5H-dibenz[b,e]azepine | HCID 67974 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Methyl-4-nitrobenzoyl chloride | HCID 3015795 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54506243 | HCID 54506243 | 65.2% |
Reaction Steps
A mixture of 1.17 g of 6,11-dihydro-5H-dibenz[b,e]azepine, 1.20 g of 3-methyl-4-nitrobenzoyl chloride, 0.80 ml of diisopropylethylamine in 25 ml of dichloromethane is stirred 18 hours at room temperature. The mixture is washed with water and dried (Na2SO4). The solution is filtered through a thin pad of hydrous magnesium silicate. The filtrate is concentrated and diluted while hot with hexane to give 1.40 g of crystals. Recrystallization from dichloromethane-hexane gives 1.26 g of crystals, m.p. 179°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05786353 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-5e06ffc4c3a74173ad7e891afa931675 |
| Source note | uspto-grants-1998_07 |