HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-N-methyl-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6,11-Dihydro-5H-dibenz[b,e]azepine | HCID 67974 | — |
| Reactant | 4-(N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride | HCID 21837092 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-N-methyl-2-methylbenzamide | HCID 15307995 | 78.1% |
Reaction Steps
A mixture of 0.291 g of 6,11-dihydro-5H-dibenz[b,e]azepine, 0.518 g of 4-[N-methyl-N-(2-methyl-benzoyl)amino]benzoyl chloride and 0.182 g of triethylamine in 10 ml of tetrahydrofuran is stirred at room temperature for 2 hours. The solvent is removed, the residue diluted with water and extracted with dichloromethane. The extract is washed with 1 N HCl water, 1M NaHCO3, brine and dried (Na2SO4). The solution is passed through a thin pad of hydrous magnesium silicate. The filtrate is concentrated and chilled to give 0.52 g of crystals, m.p. 160°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05786353 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-7f4284c7b4a040a8944273f9b3b04f1c |
| Source note | uspto-grants-1998_07 |