Sodium Hydroxide → HCID 19068260, compound

Participants

Reaction Steps

1.1 g (2.7 mmol) of the above methyl ester (b), 40 ml of THF and 40 ml of methanolic sodium hydroxide solution (2N) were introduced into a round-bottomed flask and the mixture was stirred at room temperature for eight hours. The reaction medium was evaporated to dryness and the residue was taken up in water, acidified to pH 1 and extracted with ethyl ether. The organic phase was separated out after settling had taken place, dried over magnesium sulfate and evaporated. The residue obtained was triturated from hexane, filtered and dried. 900 mg (78%) of the expected acid, having a melting point of 164°-5° C., were recovered.

Provenance & Evidence