Hydrochloric Acid → HCID 10112471, compound

Participants

Reaction Steps

962 mg (2.2 mmol) of the above methyl ester (b) and 10 ml of THF were introduced into a round-bottomed flask and 283 mg (6.7 mmol) of lithium hydroxide were added. The reaction medium was heated at reflux for 5 hours and was then poured into water and acidified to pH 1 with concentrated hydrochloric acid. The organic phase was separated out after settling had taken place, dried over magnesium sulfate and evaporated. The solid obtained was triturated from hexane, filtered off and dried. 600 mg (85%) of the expected acid, having a melting point of 232°-4° C., were recovered.

Provenance & Evidence