Potassium Hydroxide → HCID 19068426, compound

HRID 1957725Notes

Reaction equation

HRID 1957725 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]1.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:15]1([OH:18])[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 249055-BromoindoleHCID 740491-Methyl-4-piperidone

Product 1

HCID 19068426HCID 19068426, compound

Procedure

A mixture of 5-bromoindole (490 g), 1-methyl-4-piperidone (339 mL) and potassium hydroxide (15 g) in IMS (3L) was stirred under nitrogen at room temperature for 24 hrs. The mixture was cooled to 7° and filtered. The filter cake was washed with ethanol (300 mL) followed by water (800 mL) to give an off-white powder which was dried in vacuo at 50° for 24 hr (563.8 g, 73% of theory).

Workup

  1. temperatureThe mixture was cooled to 7°
  2. filtrationfiltered
  3. washThe filter cake was washed with ethanol (300 mL)
  4. customto give an off-white powder which
  5. customwas dried in vacuo at 50° for 24 hr (563.8 g, 73% of theory)

Sources & evidence

ORD record
ord-01ea360e9c8344c3b6cb3e67fea7e153
Source dataset
uspto-grants-1998_07
Patent number
US05786473

Reaction notes

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