Water → HCID 10496538, compound

Participants

Reaction Steps

In 20 mL of anhydrous tetrahydrofuran, was dissolved 2.00 g (6.02 mmol) of 2,2'-(2,3-dimethoxy-1,4-phenylene)-bis(4,4-dimethyl-2-oxazoline). Thereto, 16.4 mL of 0.92M ethylmagnesium bromide solution (15.1 mmol) in tetrahydrofuran was added dropwise with ice cooling in 30 minutes, and the mixture was stirred at room temperature for 2 hours. To the reaction liquid, were added successively 10 mL of aqueous saturated ammonium chloride solution and 30 mL of water. The product was extracted from the mixture with ether, washed with a saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed by distillation. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1) to obtain 1.98 g (100%) of 2,2'-(2,3-diethyl-1,4-phenylene)-bis(4,4-dimethyl-2-oxazoline) in a colorless prism crystal state.

Provenance & Evidence