HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957822Generated: November 4, 2026
Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride
https://huagongshe.com/reaction/1957822
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-(4-acetamidophenoxy)acetate | HCID 309738 | — |
| Product | 2-(4-Aminophenoxy)acetic acid hydrochloride | HCID 66811488 | 77.6% |
Reaction Steps
A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08409559B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-38f5b847ce1f4af9b1d105bee75bf64b |
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| Source note | uspto-grants-2013_04 |
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