Hydrochloric Acid → Benzoic acid, 2-(carboxymethoxy)-

https://huagongshe.com/reaction/1957874

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Methyl 2-(2-methoxy-2-oxoethoxy)benzoate	HCID 11287524	—
Product	Benzoic acid, 2-(carboxymethoxy)-	HCID 69461	78.2%

Reaction Conditions

Temperature	80 °C

Reaction Steps

2-Methoxycarbonylmethoxybenzoic acid methyl ester 1 (95 g, 424 mmol) was added to a 10% aqueous NaOH solution (475 ml) and heated at 80° C. for 4 hrs. The reaction mixture was cooled to room temperature and pH adjusted to 2 with dilute HCl. Crude 91 was purified by dissolving in 10% aqueous NaOH and precipitated by acidifying with HCl, to get pure 91 (65 g, 78.2%) as a white powder. M.p: 189-192° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08409559B2
Source dataset	uspto-grants-2013_04
ORD ID	ord-26735dfe882a4a9688fc4d23553d9859
Source note	uspto-grants-2013_04