1-Methylimidazole → 2,2,2-Trichloro-1-(1-methyl-1H-pyrrol-2-yl)-1-ethanone

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Reaction Steps

Under argon, 1.09 ml (12.3 mmol) of trichloroacetyl chloride are initially charged in 5 ml of DCM, and a solution of N-methylimidazole and 3 ml of DCM is added dropwise at RT over a period of 30 min. The reaction solution is allowed to stir at RT overnight and then concentrated, and the residue is purified over a flash frit (cyclohexane, cyclohexane/ethyl acetate 40:1). This gives the product as a liquid.

Provenance & Evidence