HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957952Generated: October 31, 2026
Nitric Acid → 1-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene
https://huagongshe.com/reaction/1957952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 1-(Methylsulfonyl)-3-(trifluoromethyl)benzene | HCID 2760761 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 1-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene | HCID 68423100 | 40% |
Reaction Steps
1-methanesulfonyl-3-trifluoromethylbenzene (220 mg; 1 mmol) was dissolved at 0° C. in 3 mL 98% sulfuric acid and 2 mL of 100% HNO3 were added. The mixture was heated 2 hours at 80° C. and then poured onto ice; a precipitate was isolated: 110 mg (0.40 mmol; 40% yield) of 1-methanesulfonyl-3-nitro-5-trifluoromethylbenzene were obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410100B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-09a81b0d57e74495b174a0766abaa28e |
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| Source note | uspto-grants-2013_04 |
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