HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957955Generated: October 30, 2026
Ammonium formate → N-(3-amino-5-trifluoromethyl-phenyl)-methanesulfonamide
https://huagongshe.com/reaction/1957955
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | N-[3-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide | HCID 68424558 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3-amino-5-trifluoromethyl-phenyl)-methanesulfonamide | HCID 21961371 | — |
Reaction Steps
N-(3-nitro-5-trifluoromethyl-phenyl)-methylsulfonamide (0.1 g; 0.4 mmol) ammonium formate (0.1 g; 1.8 mmol) and Raney-Nickel (16 mg) were dissolved in 0.4 mL of dioxane. The reaction was heated to 140° C. for 6 minutes in a micro wave reactor. The mixture was then diluted with dichloromethane, filtrated and the filtrate concentrated. 70 mg (0.27 mmol; 68% yield) of an orange oil were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08410100B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-acd2e04d3f67409283ddcfaa6af32f72 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
