HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 3-(methylsulfonamido)-5-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Methyl 3-amino-5-nitrobenzoate | HCID 2756518 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-(methylsulfonamido)-5-nitrobenzoate | HCID 57815097 | 89% |
Reaction Steps
3-amino-5-nitro-benzoic acid methyl ester (25 g; 0.13 mol) was dissolved in to dichloromethane (300 ml) and treated at 0° C. with 11 ml of pyridine. Methanesulfonylchloride (11 ml; 0.14 mol) was added and the reaction mixture was stirred overnight at room temperature. Water was added and the precipitate filtered and washed with dichloromethane/diethylether. 32 g (0.11 mmol; 89% yield) of 3-methylsulfonylamino-5-nitro-benzoic acid methyl ester were obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ef63bf4475214897a7df71938f397b48 |
| Source note | uspto-grants-2013_04 |