HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → N-(3-Amino-5-(methylsulfonyl)-phenyl)-methylsulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | N-(3-methyl-5-nitro-phenyl)-methylsulfonamide | HCID 68423293 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3-Amino-5-(methylsulfonyl)-phenyl)-methylsulfonamide | HCID 58154480 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of N-(3-methyl-5-nitro-phenyl)-methylsulfonamide (0.12 g; 0.4 mmol), ammonium formate (0.26 g; 4 mmol) and Raney-Nickel in 1 mL dioxane was heated at 120° C. in a microwave oven for 20 minutes. The mixture was then filtrated on a celite pad and concentrated. 70 mg (0.35 mmol; 87% yield) of a red oil were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-fb985e3e9e5d473684131008127172b7 |
| Source note | uspto-grants-2013_04 |