HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-(methanesulfonyl)-5-nitrobenzene → 3-Bromo-5-(methanesulfonyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-(methanesulfonyl)-5-nitrobenzene | HCID 54123100 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Bromo-5-(methanesulfonyl)aniline | HCID 68424184 | — |
Reaction Steps
1-Bromo-3-methylsulfonyl-5-nitro-benzene (100 mg; 0.4 mmol) was dissolved in THF (10 ml). Raney-Nickel was added and the mixture hydrogenated at 1 bar. The reaction mixture was filtrated and concentrated. 30 mg (0.16 mmol; 40%) of target compound were obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e0ab53c54971493d9876a5b29cb72920 |
| Source note | uspto-grants-2013_04 |