HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-methanesulfonyl-5-nitrobenzoate → Methyl 3-amino-5-(methylsulfonyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-methanesulfonyl-5-nitrobenzoate | HCID 43449009 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-amino-5-(methylsulfonyl)benzoate | HCID 18945412 | — |
Reaction Steps
3-(Methylsulfonyl)-5-nitro-benzoic acid methyl ester (32 g; 0.12 mol) was dissolved in methanol (300 ml), 4 g Pd/C (5%) were added and the mixture was hydrogenated at 5 bar. The mixture was filtered and the filtrate concentrated. 26 g (0.11 mmol; 94% yield) were obtained as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-99cedfc178e748d39562ad3c0b31bca9 |
| Source note | uspto-grants-2013_04 |