HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one → 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-(methylsulfonyl)amino-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one | HCID 58405900 | — |
| Reactant | Methyl 3-amino-5-(methylsulfonamido)benzoate | HCID 59243082 | — |
| Product | 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-(methylsulfonyl)amino-benzoic acid | HCID 68424966 | 35% |
Reaction Steps
Starting from 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one (1.5 g; 6.25 mmol) and 3-amino-5-(methylsulfonyl)aminobenzoic acid methyl ester (3.49 g; 14.502 mmol), 950 mg (2.18 mmol; 35% yield) of the desired product were obtained as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e0de8f1237084521a310f72a903577c6 |
| Source note | uspto-grants-2013_04 |