Formamide → HCID 178518229, compound

Participants

Reaction Conditions

Reaction Steps

A sealed tube was charged with methyl 4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carboxylate (4 g, 16.44 mmol) and formamide (40 mL, 1004 mmol). The reaction was heated at 150° C. overnight. The reaction mixture was cooled, filtered, and the solid was washed with DCM and MeOH. The solid was collected and dried under vacuum to give 3.65 g (93%) of product. LCMS (ES) m/z=239.0 (M+H)+, 1H NMR (400 MHz, DMSO-d6) δppm 12.4 (br s, 1H, NH), 8.10 (s, 1H) 3.72 (m, 4H). 3.58 (m, 4H).

Provenance & Evidence