Methyl iodide → HCID 66780292, compound

Participants

Reaction Steps

To a vial containing 4-[(3-chloro-2-methylphenyl)methyl]-2-(4-morpholinyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one (25 mg, 0.061 mmol) in Tetrahydrofuran (THF) (607 μl) was added methyl iodide (4.20 μl, 0.067 mmol). The mixture was stirred at room temperature overnight then concentrated. The residue was purified by reversed-phase HPLC to provide 4-[(3-chloro-2-methylphenyl)methyl]-5-(methylthio)-2-(4-morpholinyl)[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one. (6 mg, 23%); LC/MS: MS (ES+) m/e 423 (MH+); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.44 (s, 3H), 2.47 (s, 3H), 3.52 (m, 4H), 3.63-3.73 (m, 4H), 5.50 (s, 2H), 6.61 (d, J=7.6 Hz, 1H), 7.16 (m, 1H), 7.38 (d, J=7.8 Hz, 1H).

Provenance & Evidence