Triphenylphosphine → HCID 66780320, compound

Participants

Reaction Steps

To a solution of 2-azido-N-[(3-chloro-2-methylphenyl)methyl]-N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]acetamide (300 mg, 0.695 mmol) in Tetrahydrofuran (THF) (20 mL) and H2O (2 mL) was added Ph3P (547 mg, 2.084 mmol). The mixture was stirred at rt for 5 hr before removal of the solvent. To the residue was added 50 mL DCM and 20 mL NaHCO3 (sat.), followed by Boc2O (0.323 mL, 1.389 mmol). The mixture was stirred at rt for 17 hrs. The organic layer was concentrated and purified on a silica column to give the titled compound 150 mg. (43%) LC/MS (ES) m/z=505.9 (M+H).

Provenance & Evidence