Dimethylamine → HCID 66780426, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-N-[(3-chloro-2-methylphenyl)methyl]-N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]acetamide (100 mg, 0.235 mmol) (prepared according to the procedures of example 111) in N,N-Dimethylformamide (DMF) (2 mL) was added dimethyl amine (0.588 mL, 1.176 mmol). The mixture was heated in a microwave reactor at 120° C. for 30 mins. The resultant mixture was diluted in EtOAc (100 mL) and washed with H2O (100 ml×2). The organic layer was concentrated to afford the crude product, which was use in next step without further purification. (88%)

Provenance & Evidence