Hydrochloric Acid → HCID 66780515, compound

Participants

Reaction Steps

Sodium hydroxide (0.166 mL, 0.166 mmol) was added to a solution of [4-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-2-(4-morpholinyl)-7-oxo-4,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]methyl acetate (80 mg, 0.166 mmol) in Methanol (1.5 mL). The reaction was stirred at RT for 30 min. 1N HCl was added to adjust to pH=5. The mixture was partitioned between DCM and NaCl solution. The organic layer was concentrated to give the titled compound, 65 mg (90%). LC/MS (ES) m/z 441.0 (M+H)+, 1H NMR (400 MHz, DMSO-d6) δ ppm 7.65 (m, 1H), 7.36 (m, 1H), 6.87 (m, 1H), 5.60 (s, 2H), 4.15 (m, 2H), 3.66 (m, 4H), 3.56 (m, 4H), 2.49 (s, 3H)

Provenance & Evidence