Oxolan-3-amine → HCID 66643845, compound

HRID 1958073Notes

Reaction equation

HRID 1958073 reaction equation
CO[C:3]([C:5]1[N:6]=[N:7][C:8]([O:11][CH2:12][C:13]2[C:14]([CH2:19][CH2:20][CH2:21][CH3:22])=[N:15][O:16][C:17]=2[CH3:18])=[CH:9][CH:10]=1)=[O:4].[O:23]1[CH2:27][CH2:26][CH:25]([NH2:28])[CH2:24]1>>[O:23]1[CH2:27][CH2:26][CH:25]([NH:28][C:3]([C:5]2[N:6]=[N:7][C:8]([O:11][CH2:12][C:13]3[C:14]([CH2:19][CH2:20][CH2:21][CH3:22])=[N:15][O:16][C:17]=3[CH3:18])=[CH:9][CH:10]=2)=[O:4])[CH2:24]1

Participants

3

Reactant 2

HCID 3365553Oxolan-3-amineHCID 666438716-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester

Product 1

HCID 66643845HCID 66643845, compoundYield 92%

Procedure

As described for example 1e, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester (120 mg, 0.39 mmol) was converted, using rac-tetrahydrofuran-3-amine instead of isopropylamine, to the title compound (130 mg, 92%) which was obtained as a light yellow oil after purification by chromatography (silica, 0 to 5% methanol in dichloromethane). MS: m/e=361.5 [M+H]+.

Sources & evidence

ORD record
ord-fae9bb8da3034930a84be35b291258b6
Source dataset
uspto-grants-2013_04
Patent number
US08410104B2

Reaction notes

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