HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 4-Methyl-3-(7-oxo-6,7-dihydrothieno[2,3-d]pyridazin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 3-(5-(Tert-butylcarbamoyl)-4-formylthiophen-2-yl)-4-methylbenzoic acid | HCID 86618195 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Methyl-3-(7-oxo-6,7-dihydrothieno[2,3-d]pyridazin-2-yl)benzoic acid | HCID 68562271 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A solution of 3-(5-(tert-butylcarbamoyl)-4-formylthiophen-2-yl)-4-methylbenzoic acid (2.30 g, 6.7 mmol) in acetic acid (20 ml) was treated with hydrazine (0.73 ml, 20 mmol) and heated to 110° C. for 8 hrs. After cooling to RT the volatiles were removed in vacuo. The residue was recrystallized from MeOH. Yield: 1.01 g. MS (ESI, pos. ion) m/z: 287 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745449B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f8a2bb2e141742789ed2a7ce7dbe635c |
| Source note | uspto-grants-2010_06 |