4-Methylmorpholine → HCID 56961778, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (50 mg, 0.165 mmol) and valeric acid (36 mg, 0.247 mmol) in DMF (5 ml) were added N-methyl morpholine (51 mg, 0.5 mmol) and HBTU (94 mg, 0.247 mmol), and the reaction mixture was stirred for 16 h at 25° C. The reaction mixture was poured into water and extracted with ethyl acetate (3×20 ml). The combined ethyl acetate part was dried over Na2SO4 and evaporated to furnish the crude material (60 mg). The crude was purified by prep. HPLC and the desired product (30 mg, 47%) was obtained as sticky white solid. MS (LC/MS): 387.2 (M+H).

Provenance & Evidence