5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine → HCID 178522409, compound

HRID 1958125Notes

Reaction equation

HRID 1958125 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[NH:21]1[CH:25]=[CH:24][C:23]([C:26](O)=[O:27])=[N:22]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:26]([C:23]3[CH:24]=[CH:25][NH:21][N:22]=3)=[O:27])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamineHCID 178524567HCID 178524567, compound

Product 1

HCID 178522409HCID 178522409, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2, 2-trifluoro-ethoxy)-pyridin-3-ylamine and 1H-pyrazole-3-carboxylic acid as starting materials, MS (LC/MS): 395.2 (M−H).

Sources & evidence

ORD record
ord-20c4e9fc0e134ba0ad0b0ce818cbd052
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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