2-Methylnicotinic acid → HCID 56961607, compound

HRID 1958130Notes

Reaction equation

HRID 1958130 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:21][C:22]1[C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=[CH:24][N:23]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:28]([C:27]3[C:22]([CH3:21])=[N:23][CH:24]=[CH:25][CH:26]=3)=[O:29])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6433732-Methylnicotinic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56961607HCID 56961607, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2, 2-trifluoro-ethoxy)-pyridin-3-ylamine and 2-methyl-3-pyridinecarboxylic acid as starting materials, MS (LC/MS): 421.8 (M+H).

Sources & evidence

ORD record
ord-191f0219f70d48ea8b6f032e6249b315
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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