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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958142Generated: October 26, 2026

5-Methylnicotinic acid → N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-methylnicotin-amide

https://huagongshe.com/reaction/1958142

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methylnicotinic acidHCID 256208—
Reactant5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamineHCID 67281315—
ProductN-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-methylnicotin-amideHCID 56961334—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2, 2-trifluoro-ethoxy)-pyridin-3-ylamine and 5-methyl-3-pyridinecarboxylic acid (CAN 3222-49-9) as starting materials; MS (EI) 422.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08410107B2
Source datasetuspto-grants-2013_04
ORD IDord-3bb400d213814093bc6a271e0f6a4109
Source noteuspto-grants-2013_04