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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958149Generated: October 31, 2026

Nicotinic Acid → (S)-N-(5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-yl)nicotinamide

https://huagongshe.com/reaction/1958149

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNicotinic AcidHCID 938—
Reactant5-(4-Chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamineHCID 67281594—
Product(S)-N-(5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-yl)nicotinamideHCID 56961333—

Reaction Steps

The title compound was synthesized in analogy to Example 42g, using 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine (example 420 and 3-pyridine carboxylic acid (CAN 59-67-6) as starting materials; MS (EI) 422.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08410107B2
Source datasetuspto-grants-2013_04
ORD IDord-240ca0a4d47e45348835d5ebf942a331
Source noteuspto-grants-2013_04