HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-fluorophenylboronic Acid → N-(5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotin-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-fluorophenylboronic Acid | HCID 2778656 | — |
| Reactant | N-(5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide | HCID 67280716 | — |
| Product | N-(5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotin-amide | HCID 56961389 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 39, using N45-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide (example G) and B-(4-chloro-3-fluorophenyl)-boronic acid (CAN 137504-86-0) as starting materials; LC-MS (UV peak area/ESI) 96.4%, 424.0482 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c26a11edd7da43b2a5929115d0cb1c75 |
| Source note | uspto-grants-2013_04 |