HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → N-(5-(3-chloro-4-fluorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotin-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | N-(5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide | HCID 67280716 | — |
| Product | N-(5-(3-chloro-4-fluorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotin-amide | HCID 56961390 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 39, using N45-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide (example G) and B-(3-chloro-4-fluorophenyl)-boronic acid (CAN 144432-85-9) as starting materials; LC-MS (UV peak area/ESI) 98.0%, 424.0483 (M-H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6673c771a79f4ae9b46721be3b42cc47 |
| Source note | uspto-grants-2013_04 |