3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 56961393, compound

Participants

Reaction Conditions

Reaction Steps

6-(4-Chloro-phenyl)-5-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyrazin-2-ylamine (0.100 g, 315 μmol) was dissolved in dried pyridine (1.0 mL), nicotinoyl chloride hydrochloride (61.6 mg, 346 μmol) was added and the suspension was stirred at 140° C. for 10 minutes in the microwave. The solvent was evaporated and the crude material was purified by flash chromatography (silica gel, 10 g, 0% to 50% CH2Cl2/MeOH/NH3 9/1/0.1) to give 0.121 g (91%) of the title compound as white solid; LC-MS (UV peak area/ESI) 100%, 423.0821 (M+H)+.

Provenance & Evidence