3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 56961449, compound

HRID 1958157Notes

Reaction equation

HRID 1958157 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[N:10][C:9]=2[O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:4][CH:3]=1.Cl.[C:22](Cl)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[N:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([NH:14][C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[N:25][CH:24]=3)[CH:11]=[N:10][C:9]=2[O:15][CH2:16][C:17]([F:18])([F:20])[F:19])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 67280365HCID 67280365, compound

Product 1

HCID 56961449HCID 56961449, compound

Procedure

The title compound was synthesized in analogy to Example 48e, using 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazin-2-ylamine (example 49d) and nicotinoyl chloride hydrochloride as starting materials; LC-MS (UV peak area/ESI) 95.7%, 407.0532 (M−H)−.

Sources & evidence

ORD record
ord-e055772d313242a0bf36b81d7bac03d5
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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